Colts-Cardinals Week 6 preview focuses on a battle where Indianapolis aims to push ahead with a high‑usage offense while Arizona leans on a stout three‑quarter defense that struggles late. Murray delivers solid moments but hasn’t elevated the team, and Arizona’s late‑game lapses have haunted them. The Colts rely on Marvin Harrison Jr. and Tre[y] McBride, with Elijah Higgins providing upside. If Brissett starts, Indy should control the clock and tempo for a relatively smooth win, 27–16.

Arizona Cardinals TE Tip Reiman was placed on injured reserve, ending his season after four games. He logged 3 receptions for 18 yards over 98 offensive snaps and 50 on special teams.

With Reiman out, the Cardinals will deploy a three‑tight end look featuring Trey McBride, Elijah Higgins and Travis Vokolek, while Josiah Deguara and Nick Muse remain on the practice squad. No 53‑man move has been made yet, keeping active depth in flux as the team prepares for Sundays matchup with the Indianapolis Colts.

The club could wait until Saturday to add a body and adjust the roster for Week 9, prioritizing depth at tight end and special teams as they evaluate injuries and practice squad elevations.